The present invention relates to compounds that modulate neurotransmission
by promoting the release of neurotransmitters such as acetylcholine,
dopamine and norepinephrine. More particularly, the present invention
relates to thio-bridged aryl compounds that are capable of modulating
acetylcholine receptors and pharmaceutical compositions comprising such
compounds. The compounds disclosed are useful for the treatment of
dysfunctions of the central and autonomic nervous systems.