The present invention provides vaccine compositions of attenuated human
rotavirus. More particularly, the attenuated human rotavirus is produced
by cold passage and thus contains attenuating mutations which produce
virus having a cold-adapted (ca) and temperature sensitive (ts)
phenotype. The attenuated strains are used in methods for stimulating the
immune system of an individual to induce protection against human
rotavirus by administration of the ca attenuated rotavirus.