The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives
of general formula I: ##STR00001## that bind with high affifnity to
CRF.sub.1 receptors, including human CRF.sub.1 receptors. This invention
also relates to methods of using the compounds of the invention to treat
a disorder or condition, the treatment of which can be effected or
facilitated by antagonizing a CRF receptor, such as CNS disorders or
diseases, particularly anxiety disorders, and depression and stress
related disorders.