A wireless communication system is disclosed. An available frequency spectrum is divided into multiple channels, a first wireless communication coverage unit is then segregated into a first number of geographical segments. After the segregated channels are grouped into a second number of channel blocks, each channel block is assigned to the segregated geographical segments with predetermined priorities. The above steps are repeated in a fashion that the channels in different channel blocks exhibit no higher mutual interference than the channels in the same channel block, and the channel block assigned for each segregated segment of the first wireless communication coverage unit is different from the channel block assigned for the segregated segment of a second wireless communication coverage unit that immediately borders with the segregated segment of the first wireless coverage unit even if the first and second wireless communication coverage units share the same frequency spectrum.