Indole derivatives represented by formula (I) ##STR00001## wherein all symbols represent the same as that in specification), production methods thereof, and DP receptor antagonist comprising them as active ingredients.Since the compounds of formula (I) binds and antagonizes to DP receptor, they are useful for the prevention and/or treatment against allergic diseases, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis.