Systems and methods for performing programmatic queries about molecular and biomolecule information. The methods comprise creating one or more databases of molecular data formatted or conditioned according to a directory service protocol, forming, by a user, a query based on a molecular identifier or other molecular indicia, submitting the query to a name server, performing a lookup in the databases based on the molecular name or identifier, retrieving a query result or results from the databases, and returning the query results to the user. The systems comprise at least one client computer, at least one name server operatively coupled to the client computer, at least one database operatively coupled to the name server and containing data formatted or conditioned according to a directory service protocol, at least one client application configured to generate queries based on molecular identifiers and receive results based the queries, and a directory service associated with the name server configured perform lookups in the database based on the query and retrieve results responsive to the query.