A comprehensive dietary supplement of bioavailable minerals, vitamins, phytonutrients, herbs, antioxidants, and enzymes for ameliorating the effects of stress and premature aging, for enhancing natural cellular rejuvenation and regeneration, and for fortifying the immune system of a warm-blooded animal or human, comprises, in parts by weight (a) about 100 500.times.10.sup.-3 of a blend of vitamins, (b) about 200 800.times.10.sup.-3 of blend of minerals wherein said minerals are present as amino acid chelates formed from an amino acid ligand and said minerals, wherein the mole ratio of amino acid ligand to mineral in said chelate is at least 1:1, (c) about 250 750.times.10.sup.-3 of a blend of phytonutrients, (d) about 50 500.times.10.sup.-3 of a blend of herbs, and (e) about 30 500.times.10.sup.-3 of a blend of enzymes.