Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.7a, R.sup.8, R.sup.8a, R.sup.9, R.sup.9a, R.sup.10 and R.sup.10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.