The present invention describes a novel controlled release multilayer
composition that is capable of delivering a first active agent from one
layer immediately followed by continuous controlled delivery of second
active agent from matrix forming layer while the dosage form floats and
is retained in the fluid of the environment. The floating bilayer system
comprises of immediate release layer containing one active agent and a
disintegrating agent whereas second floating matrix forming layer
comprises a gas generating component, a gelling agent, and a second
active agent. The present invention relates more particularly to a
controlled release fluoroquinolone compositions, which maintain a
therapeutically effective blood concentration of fluoroquinolone for
duration with once a day administration.