Structural panels for use in manufacturing aircraft fuselages and other structures are disclosed herein. In one embodiment, a structural panel configured in accordance with the invention includes a skin having at least one offset surface. The structural panel can further include at least first and second stiffeners. The first stiffener can have a first flange portion mated to the skin adjacent to the offset surface. The second stiffener can be spaced apart from the first stiffener and can similarly have a second flange portion mated to the skin adjacent to the offset surface. The structural panel of this embodiment can additionally include a support member mated to the first flange portion of the first stiffener, the second flange portion of the second stiffener, and the offset surface of the skin.