The present invention provides hapten derivatives useful for the
preparation of antigens, antibodies and reagents for use in immunoassays
for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present
invention, the 2-oxy LSD nucleus is derivatized out of the indole
nitrogen to form an aminoalkyl derivative. The resulting haptens can then
be further modified at this functionalized position for linking to
appropriate immunogenic or labeling groups to provide reagents for
immunoassays having substantially equal specificity for both LSD and
2-oxo-3-hydroxy-LSD.