The present invention provides compounds of formula (I) including
stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates
thereof (Formula (I)) wherein the dashed line may represent a double
bond; R is aryl or heteroaryl, each of which may be substituted by 1 to 4
groups J selected from: halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6
alkyl, C2-C6 lkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, --C(O)R.sub.2,
nitro, hydroxy, --NR.sub.3R.sub.4, cyano and or a group Z; R.sub.1 is
hydrogen, C3-C7 cycloalkyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl,
C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkyl, halo C1-C6 alkoxy,
halogen, NR.sub.3R.sub.4 or cyano; D, G is --C-- optionally substituted;
X is carbon or nitrogen; Y is nitrogen or --C-- optionally substituted; W
is a 4-8 membered ring, which may be saturated or may contain one to
three double bonds, and in which:--one carbon atom is replaced by a
carbonyl or S(O).sub.m; and--one to four carbon atoms may optionally be
replaced by oxygen, nitrogen or NR.sub.12, S(O).sub.m, carbonyl, and such
ring may be further substituted by 1 to 8 substituents; Z is a 5-6
membered heterocycle, which may be substituted by 1 to 8 R.sub.5 groups
or a phenyl ring, which may be substituted by 1 to 4 substituents; m is
an integer from 0 to 2. to processes for their preparation, to
pharmaceutical compositions containing them and to their use in the
treatment of conditions mediated by corticotropin-releasing factor (CRF).