A display panel supporting device with cushion mechanism comprising a fixed supporting column, a sliding column fitted into the supporting column and arranged to move in sliding manner relative to the fixed supporting column for adjusting the height of the display panel and a cushion mechanism installed between the fixed supporting column and the sliding column and arranged to move synchronously with the sliding column, and the cushion mechanism has the effect of increasing the friction force between the supporting column and the sliding column, and the friction force can remain unchanged even after a long period of use that can improve the function of height adjusting, and prolong the service life of the display panel supporting device.