A tape drive has a front panel with an opening therein for receiving tape cartridges, and contains tape drive electronics. For transferring data into and out the tape drive electronics, the tape drive electronics includes a USB or Firewire serial data port, and the front panel of the tape drive has an access opening therein, behind which the serial port is mounted, so that a serial cable connector can be plugged into the serial port from the front panel of the tape drive. Alternatively, a data transfer cartridge can be inserted into the opening of the tape drive that is normally used for tape cartridges, the data transfer cartridge having a front side that is accessible via the opening in the front panel of the drive, and a USB or Firewire connector is disposed in the front side of the data transfer cartridge. A connector at the rear side of the data transfer cartridge communicates with the serial port at the front side, and mates with a connector in the tape drive when the data transfer cartridge is inserted therein.