A novel method of screening herbal composition for a pharmaceutically active component of interest ("target component") comprises: immobilizing a plurality of receptors of interest on a chip; flowing the herbal composition through the chip to allow binding of the target component with the receptors; disassociating the bound target component from the immobilized receptors on the chip; profiling the disassociated target component by HPLC; and identifying the target component based on the HPLC profile of the disassociated target component.