A cotton cultivar, designated DPX 08Q912DF, is disclosed. The invention relates to the seeds of cotton cultivar DPX 08Q912DF, to the plants of cotton DPX 08Q912DF and to methods for producing a cotton plant produced by crossing the cultivar DPX 08Q912DF with itself or another cotton variety. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar DPX 08Q912DF with another cotton cultivar.