This invention relates to N-aroyl piperazine derivatives of formula (I),
wherein: Y represents NR.sup.2; m represents 1, 2 or 3; p represents 0 or
1; X is O, S, C.dbd.O, SO.sub.2, or CH.dbd.CH--; Ar.sup.1 is aryl, or a
mono or bicyclic heteroaryl group containing up to 4 heteroatoms selected
from N, O and S; any of which may be optionally substituted; Ar.sup.2
represents phenyl or a 5- or 6-membered heterocyclyl group containing 1
to 3 heteroatoms selected from N, O and S, wherein the phenyl
heterocyclyl group is substituted by R.sup.1 and further optional
substituents; or Ar.sup.2 represents an optionally substituted bicyclic
aromatic or bicyclic heteroaromatic group containing 1 to 4 heteroatoms
selected from N, O and S; R.sup.1 represents optionally substituted
(C.sub.1-4)alkoxy, halo, optionally substituted (C.sub.1-6)alkyl,
optionally substituted phenyl, or an optionally substituted 5- or
6-membered heterocyclic ring containing 1 to 4 heteroatoms selected from
N, O and S; R.sup.2 represents hydrogen, optionally substituted
(C.sub.1-4)alkyl, optionally substituted (C.sub.1-6)alkanoyl, optionally
subtituted (C.sub.1-6)alkanoxycarbonyl or optionally substituted
aryl(C.sub.1-6)alkyloxycarbonyl; and their use as orexin
receptor-antagonists.