Disclosed herein are compounds of the formula ##STR00001## wherein R.sub.1 is independently H or alkyl of 1 to 6 carbons; R.sub.2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br, I, CF.sub.3, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons; n is an integer of between 0 and 2; o is an integer between 0 and 3; R.sub.3 is hydrogen, lower alkyl of 1 to 6 carbons, F, Cl, Br or I; R.sub.4 is heteroaryl or (R.sub.5).sub.p-heteroaryl where the heteroaryl group is 5-membered or 6-membered and has 1 to 3 heteroatoms selected from the group consisting of O, S, and N; p is an integer having the values of 0 5; R.sub.5 is F, Cl, Br, I, NO.sub.2, N(R.sub.8).sub.2, N(R.sub.8)CORO.sub.8, N(R.sub.8)CON(R.sub.8).sub.2, OH, OCOR.sub.8, OR.sub.8, CN, COOH, COOR.sub.8, C.sub.1-10 alkyl, fluoro substituted C.sub.1-10 alkyl, C.sub.2-10 alkenyl having 1 to 3 double bonds, C.sub.2-10 alkynyl having 1 to 3 triple bonds, or a (trialkyl)silyl or (trialkyl)silyloxy group where the alkyl groups independently have 1 to 6 carbons; A is (CH.sub.2).sub.q where q is 0 5, C.sub.3-6 branched alkyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkenyl having 1 or 2 double bonds, or C.sub.2-6 alkynyl having 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COORO.sub.8, CONR.sub.9R.sub.10, CH.sub.2OH, CH.sub.2OR.sub.11, CH.sub.2OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13O, COR.sub.7, CR.sub.7(OR.sub.12).sub.2, CR.sub.7OR.sub.13O, or Si(C.sub.1-6alkyl)3; R.sub.7 is C.sub.1-5 alkyl, C.sub.3-5 cycloalkyl, or C.sub.2-5 alkenyl; R.sub.8 is C.sub.1-10 alkyl, C.sub.1-10 (trimethylsilyl)alkyl, or C.sub.5-10 cycloalkyl; R.sub.9 and R.sub.10 are independently hydrogen, C.sub.1-10 alkyl, C.sub.5-10 cycloalkyl, phenyl or R.sub.12-phenyl; R.sub.11 is C.sub.1-6 alkyl, phenyl, or R.sub.12-phenyl; R.sub.12 is C.sub.1-6 alkyl; and R.sub.13 is divalent alkyl radical of 2 5 carbons.