The present disclosure relates to compositions, including transgenic and methods relating to the characterization of gene function. Specifically, the present disclosure provides transgenic mice comprising mutations in a PPAR gene. The present disclosure also provides methods for identifying agents that modulate PPAR expression and function, useful models, and potential treatments for various disease states and disease conditions.

 
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> siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)

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