The invention relates to a device for securing the single reed (2) on the mouthpiece (1) of a wind instrument, for example a clarinet or a saxophone, by which a substantially even pressure on the surface (2') of the single reed (2) and thus on the support surface (8') of the mouthpiece (2) can be achieved. The securing device comprises a ligature (3) that is placed around the mouthpiece (1) and the single reed (2), and a ligature screw (4) with a right-hand or left-hand thread (6,7) engaging with the threads of a bolt (15,15') that extends through the eyes (14,14') of the ligature (3) . The single reed (2) can be easily and securely fastened or unfastened on the mouthpiece of the musical instrument by turning the ligature screw (4).