A library of macrocyclic compounds of the formula (I) ##STR00001## where part (A) is a ##STR00002## bivalent radical, a --(CH.sub.2).sub.y-- bivalent radical or a covalent bond; where part (B) is a ##STR00003## bivalent radical, a --(CH.sub.2).sub.z-- bivalent radical, or a covalent bond; where part (C) is a ##STR00004## bivalent radical, a --(CH.sub.2).sub.t-- bivalent radical, or a covalent bond; and where part (T) is a --Y--L--Z-- radical wherein number Y is CH.sub.2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assay or as intermediates for the synthesis of other compound of pharmaceutical interest. A process for their preparation of these compounds in a combinatorial manner, is also disclosed.