The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent induces of a range of immune responses.

 
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> Methods for preparing 7-(2'-substituted-.beta.-D-ribofuranosyl)-4-(NR.sup.2R.sup.3)-5-(substitu- ted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
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