The present invention provides compounds of the Formula I and II: ##STR00001## wherein R.sup.1, R.sup.3, W, Z, X.sup.1, X.sup.2, Ar.sup.1, R.sup.8 and R.sup.9 are as defined herein, and methods and intermediates for their preparation and uses thereof.

 
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> Compounds and pharmaceutical compositions comprising same

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