A quick-release guide assembly for an external fixation system has a body with at least one hole and a handle portion with a handle bar. The device body comprises at least one extension having a first coupling portion. The handle comprises a complementary second coupling portion, wherein one coupling portion comprising a spring actuated locking pin, wherein an actuator knob is provided to release the locking pin. Therefore the coupling portion of the handle can be releasably attached to the guide body, enabling a quick change of device bodies having different oriented and arranged holes.