The invention is involved in epimeredinoside A with its structure showed below, and the preparative methods of the pharmaceutics made from Epimeredi indica root extract containing epimeredinoside A. It includes all kinds of oral pharmaceutics made up with Epimeredi indica root extract and pharmaceutical adjuvant. The root extract is the extracta sicca prepared by water extracted and concentrated of Epimeredi indica root, containing 0.10% to 1.50% of epimeredinoside A. The invention, pharmaceutics of Epimeredi indica root extract DO NOT contain any hormone. NO progesterone is needed to be intaken to prevent the side effect after using the drug. The pharmaceutics has doubtless effect in clinic, and is stability, controllable and safety, especially compatible for the female menopause.