Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: ##STR00001## wherein each of n.sub.1, n.sub.2, and n.sub.3 is an integer of 1; each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 is independently a hydrogen atom; A.sub.1 is imidazole; A.sub.2 is imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH.sub.2; D is a group represented by -Q-Y--B, wherein Q is NR.sub.12 and R.sub.12 is a hydrogen atom or an alkyl group; Y is (CH.sub.2)m.sub.3 and m.sub.3 is an integer of 2 to 4; and B is N(R.sub.25R.sub.26), wherein each of R.sub.25 and R.sub.26 are independently a hydrogen atom, a C.sub.1 C.sub.6 alkyl group or a C.sub.3 C.sub.6 cycloalkyl group.