A method of and system for controlling image quality in a digital image printing system, such as a medical image printing system, is provided a digital medical image including a set of pixels, each of which has a pixel value, is acquired from a medical image source. A medical image printer prints the medical image on media to produce a medical image print. A device measures the density of at least a subset of the set of pixels on said medical image print to produce a measured density image. There is calculated for at least the subset of the set of pixels of the digital medical image a predicted density image. The measured density image and the predicted density image are compared to produce density corrections, if any; and any density corrections are used in printing subsequent digital medical images to improve image quality thereof.