A method and system for determining patient states is provided. The method includes the steps of data mining a patient record using a domain knowledge base relating to a disease of interest; inputting the mined data into a model of the disease of interest; and determining a state of the patient based on the model. The system includes a data miner for mining information from a patient record using a domain knowledge base relating to a disease of interest; and a processor for creating a patient model of the disease of interest, processing the mined data in the model to determine a current state of the patient and future states for different courses of treatment, and recommending a therapy based on the determined future state.