Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds
can act as selective modulators or CRF receptors. Compounds of the
invention are provided by the following formula: ##STR00001## The
5-substituted-2-arylpyrazine compounds provided herein are useful in the
treatment of a number of CNS and periphercal disorders, particularly
stress, anxiety, depression, cardiovascular disorders, and eating
disorders. Methods of treatment of such disorders and well as packaged
pharmaceutical compositions are also provided.Compounds provided are also
useful as probes for the localization of CRF receptors and as standards
in assays for CRF receptor binding. Methods of using the compounds in
receptor localization studies are given.