An apparatus for high-throughput analysis of compound absorption in a
controlled environment that closely resembles in-vivo conditions. The
apparatus includes at least one tissue-receiving enclosure that is
capable of interfacing (e.g., via transfer of fluids, electronically,
etc.) with a variety of preparative devices and analytical
instrumentation. In some variations, the tissue-receiving enclosure is
formed from two housings, which, when engaged, have a capsular shape. The
enclosure receives a tissue sample in the form of an un-everted or
everted intestinal segment or tubular artificial membrane. The tissue
sample is coupled to a generally cylindrical tissue support. The tissue
support and the enclosure are axially aligned, and openings at the ends
of the enclosure align with openings at the ends of the tissue support.
Two feed fittings, one for each end of the enclosure, forcefully mate
with the aligned openings in the housing and the tissue support. The feed
fitting seals against the ends of the tissue support, forming "outer" and
"inner" chambers within the enclosure, with the intestinal tissue being
the interface between the chambers. It is across this interface that
absorption occurs.