This invention relates to methods for diagnosing Alzheimer's Disease (AD)
by determining the level or function of insulin, insulin-like growth
factors, their receptors and/or their downstream signaling molecules. The
invention further relates to methods for the treatment of AD by
administering an insulin agonist and an insulin-like growth factor
agonist. The invention additionally provides an animal model of AD and
methods of screening for agents useful in the treatment, amelioration, or
prevention of AD.