This invention relates to compounds of formula (I): Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as described herein. The invention further relates to a method for prevention and therapeutic use thereof.
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> RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
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