System and method of wireless remote control of various defense systems installed aboard an airplane, wherein such defense systems comprise at least one of releasing gases, releasing chemical sprays, fogging, spraying sticky glue, firing laser guns, and sounding alarms. Small easy to conceal, microprocessor based transmitter means communicate with receivers, which are configured and adapted to be part of the control circuitry for the defense measures aboard the airplane. The transmitter means further have bi-directional telemetry means, to facilitate communications among crew members and ground personnel, while hostile situation is likely or is present aboard the aircraft. In one aspect of the invention the transmitter means can also activate auto flight navigation system, if required. The wireless remote control system of the invention can have more than one type of transmitter, with various levels of software lockouts, for different crew members to activate the defense systems.