A method, system, and apparatus for the collection, analysis, and disposal of controlled substances are described. A collector receives an excess of controlled substance and stores the controlled substance so that unauthorized access is minimized. An analysis determines the chemical composition and concentration. The results of the analysis are reviewed and reconciled against information in an overseeing authority information system or against information provided by the depositor of the controlled substance or both. The controlled substance is disposed of once it has been confirmed that the substance deposited in the collector is the same substance claimed to be deposited and the same substance issued by the pharmacy or other qualified authorities.