The present invention is directed to a cleaning composition comprising: (a) an enzyme in an amount effective to promote cleaning; (b) viable microorganisms in an amount effective to degrade and promote the degradation of organic materials; (c) a surfactant; and (d) an aqueous carrier; said cleaning composition maintaining at least 95% enzymatic activity at a pH range of from about 5.5 to about 13.5.

 
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> Galactosylceramide analogs, and .beta.-glucocerebrosidase activators, external skin preparations and method of activating .beta.-glucocerebrosidase using the analogs

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