System and method for performing dynamic routing in a measurement system to perform a measurement task. The system includes a computer and one or more measurement devices. One or more topography descriptions (TD) representing connectivity between devices and/or device components in the measurement system are received and preprocessed to generate corresponding graphs. A routing expert receives and analyzes a routing specification indicating source and destination terminals in the measurement system. The system dynamically computes a plurality of routes from the source terminal to the destination terminal by traversing the graphs and selecting the plurality of routes based on a metric. The computed routes are stored in a run-time specification for use at runtime to perform the measurement task. At runtime, a route is selected from the plurality of routes, and the system configures the one or more measurement devices with the selected route for performing the measurement task.