The invention relates to a method and an Automatic Gain Control (AGC) unit for automatically minimizing the impact of inter-cell interference and/or interference between co-existing systems. The AGC unit is located within a transceiver unit, the transceiver unit is located in a radio base station in a Code Division Multiple Access (CDMA) telecommunication system and the AGC unit is connected to a High Power Amplifier SPA) unit adapted to transmit radio signals to a mobile terminal and to a Low Noise Amplifier (LNA) unit adapted to receive radio signals from a mobile terminal, the High Power Amplifier (HPA) unit comprises means for automatically adoption of a maximum output power level adapted to the current inter-cell interference and/or interference between co-existing systems wherein the AGC unit comprises means for controlling the output power levels of the output signals of the HPA unit by an AGC unit by using estimated interference related parameters.