It has been discovered that .beta.-L-2'-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering a .beta.-L-2'-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. In addition, a method for preventing lamivudine resistant HBV (M552V) mutation from occurring in a naive host is provided that includes administering a .beta.-L-2'-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. A method for preventing and/or suppressing the emergence of the HBV double mutant (L528M/M552V) in a host is also provided that includes administering a .beta.-L-2'-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug.

 
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> Interferon antagonists useful for the treatment of interferon related diseases

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