The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25.degree. C. or 37.degree. C. to produce high virus titers. Both ionic and non-ionic detergents can be used in the present invention.

 
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> Allo and auto-reactive T-cell epitopes

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