A variety of ocular diseases and conditions can be treated using corticosteroids or other compounds having glucocorticoid activity. A consequence of administration of such compounds is elevated intraocular pressure, which causes undesirable side-effects. The unwanted consequences of such elevated intraocular pressure may be prevented or treated through the administration of a steroid antagonist sufficient to counter the deleterious effect of the corticosteroid or other compound having glucocorticoid activity in the anterior chamber of the eye without countering the therapeutic effect of the treatment compound.