A RF front-end having two antenna switches operatively connected to two separate antennas. The antenna switches can be used to route various transmit and receive paths to the antennas. In particular, one of the antenna switches has three switch position for use in selectively routing the 2 GHz receive paths, and another antenna switch has six switch positions for use in selectively routing the 2 GHz transmit paths and the 1 GHz signal paths. With the disclosed topology, the front-end can be used to support GSM and W-CDMA communications in many regional variants in the world. The supported variants include US1, US2, EU1, EU2 and EU/US modes. The same front-end can also be used in BT/WLAN connectivity. For MIMO purposes, one more antenna switch for the 2 GHz receive paths can be added to the same RF front-end.