Methods and systems for processing vesicants as well as other irritants are described. In some methods a vesicant, for example, a Lewisite such as the L1 form, the L2 form, L3 form, or combination thereof, is combined with permanganate, for example, as an aqueous solution of sodium permanganate. The methods can include releasing the vesicants or irritants from a munition, for example, by explosively rupturing the munition.