An endoscopic staple and related stapling device that can be used in conjunction with flexible or rigid endoscopy. The staple can also be used for other surgical procedures. The invention relates to performing a stapling operation on internal body tissues as part of a surgical procedure, diagnostic procedure or therapeutic procedure. This invention includes a surgical staple, an associated staple holder, and an associated staple delivery and deployment device. The staple holder and delivery system have a design iteration whereby the holder can be reloaded with additional staples to be used on the same patient. There is another design iteration whereby the staple holder and stapler are reusable after appropriate cleaning and sterilization.