Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, --CH.sub.2-- or --CH.sub.2CH.sub.2--; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R.sub.1 and W, R.sub.1 is (CH.sub.2).sub.n--CH(OR.sub.2)--(CH.sub.2).sub.mE.sub.1, --(CH).dbd.C(OR.sub.2)--(CH.sub.2).sub.mE, --(CH.sub.2).sub.n--CH(Y)--(CH.sub.2).sub.mE or (CH).dbd.C(Y)--(CH.sub.2).sub.mE; wherein E is COOR.sub.3, C.sub.1 C.sub.3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C.sub.1 C.sub.6 alkyl, haloalkyl and aryl-C.sub.0-4-alkyl; R.sub.2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, --COR.sub.4, --COOR.sub.4, --CONR.sub.5R.sub.6, --C(S)R.sub.4, --C(S)OR.sub.4 or C(S)NR.sub.5R.sub.6, R.sub.3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O--, CH.sub.2--, --CH.sub.2CH.sub.2-- or CH.dbd.CH-- and is bonded to a carbon atom in Phenyl Ring A that is ortho to R.sub.1. R.sub.4 R.sub.6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2 ##STR00001##

 
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> Indazole derivatives as CRF antagonists

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