A process for preparing
(R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carb-
onyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester
comprising: (a) reduction of
5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl-
]-1H-pyrrol-1-yl]-3-oxo-1-pentanoic acid,
(R)-2-hydroxy-1,2,2-triphenylethyl ester; (b) hydrolysis of
(R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carb-
onyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid,
(R)-2-hydroxy-1,2,2-triphenylethyl ester using an alkali base in a
solvent to form the acid; (c) alkylation of the acid forming
(R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carb-
onyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester.