The invention relates to a gelable copolymer composition comprising a
copolymer in a solvent. The copolymer has the structure A(B)n, wherein
the core (A) is soluble in the solvent, the arms (B) are convertible
between soluble and insoluble in the solent depending on an environmental
condition, and n>1. The composition forms a gel under environmental
conditions in which B is insoluble, through formation of B aggregates.
Block copolymers comprising polyethylene glycol (PEG) and
poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient
temperature under aqueous conditions and a gel form at body temperature
are disclosed. Copolymer compositions according to the invention can be
used to form in situ implants useful in slow-release formulations of
biologically active molecules ##STR00001##