Disclosed are the preparation and pharmaceutical use of novel noncyclic
1,3-dicarbonyl compounds of formula I, wherein ring A, ring B, R.sup.1,
R.sup.2, R.sup.3, R.sup.4, R.sup.5, X, Y, Z, Q, Ar and n are as defined
in the specification. These compounds, as peroxisome
proliferator-activated receptor (PPAR) dual agonists for both
RXR/PPARgamma and RXR/PPARalpha heterodimers, are useful in the treatment
and/or prevention of type 2 diabetes and associated metabolic syndrome
such as hypertension, obesity, insulin resistance, hyperlipidemia,
hyperglycemia, hypercholesterolemia, atherosclerosis, coronary artery
disease, and other cardiovascular disorders ##STR00001##