According to one aspect of the present invention, internal medical devices are provided which include one or more extruded regions, each of which may be formed from one or more extruded portions, which extruded portions may, in turn, contain one or more polyelectrolyte species. The one or more extruded regions may be, for example, at least partially freestanding or at least partially disposed over a substrate. The one or more extruded regions may be formed, for example, using various processes.