A processing unit for a multiprocessor data processing system includes a processor core including a store-through upper level cache, an instruction sequencing unit that fetches instructions for execution, a data register, and at least one instruction execution unit. The instruction execution unit, responsive to receipt of a load-reserve instruction from the instruction sequencing unit, executes the load-reserve instruction to determine a load target address. The processor core, responsive to the execution of the load-reserve instruction, performs a corresponding load-reserve operation by accessing the store-through upper level cache utilizing the load target address to cause data associated with the load target address to be loaded from the store-through upper level cache into the data register and by establishing a reservation for a reservation granule including the load target address.