The present invention relates to a method and apparatus for forming
agarose or cored agarose beads. The process involves dissolving/gelation
the agarose in a suitable liquid, mixing it with a hydrophobic liquid to
form an emulsion and maintaining that emulsion at a temperature equal to
or greater than the gelation point of the agarose, passing it through a
static mixer to create agarose droplets and solidifying the agarose
droplets in a second bath of hydrophobic liquid. The beads can then be
washed and used or further processed to crosslink the agarose and/ or add
various functionalities on to the agarose. Another method for solidifying
the agarose droplets is by using a heat exchanger to cool the stream
continuously after it exits the static mixer. A similar process is used
for the "cored" beads except cores, preferably in bead form, are
introduced to the agarose before it enters the first hydrophobic liquid
so that the agarose forms a coating on the cores. A similar process with
either agarose beads (made by this or another process) or cored agarose
(made by this or another process) can be used to add multiple layers of
agarose on to the existing beads. An apparatus for running the process is
also disclosed.